Assessment of cerebral hemodynamics in multiple sclerosis patients

Abstract Background Multiple sclerosis (MS) is the most common demyelinating disease of central nervous system. Autonomic dysfunction present in a wide range patients (15–80%) that might with abnormalities regulation cardiovascular system, sleep disturbance, urinary symptoms, sexual problems, and temperature problem. Although predominant view an autoimmune inflammatory condition, changes brain vasculature can occur contribute to pathophysiology. Objectives The aim this study was evaluate cerebral hemodynamics assess autonomic MS explore its relationship status. Methods Eighty diagnosed according McDonald criteria 2017 were recruited comparative cross-sectional study. All participants underwent assessment through transcranial Doppler ultrasonography. Cerebral vasomotor reactivity (CVR) hypercapnia measured by breath-holding index (BHI). They also assessed for questionnaire blood pressure measurements both erect supine positions. Results BHI values showed decreased CVR significantly lower SPMS than RRMS patients. functions more affected total score 2.58 ± 1.13 group 4.05 1.04 group. Conclusions Cerebrovascular hemodynamic insufficiency may be secondary downstream effects neuro-inflammatory cascades.